- Rb1 (Tumor Suppressor Protein) Antibody
- MyBioSource.com
- Pricing InfoSupplier PageView Company Product Page
- MBS4380201
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Monoclonal
- Human, Mouse. Others not known
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- Immunohistochemistry (IHC) Formalin
- Rabbit
- 105kDa
- Rb1
- RB transcriptional corepressor 1
- pRb, PPP1R130, pp110, RB, p105-Rb, OSRC
- Unconjugated
- IgG
- RB1/2313R
Specifications/Features
Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma